| DB ID | MyCo_2349 |
| Title | Delta-like canonical Notch ligand 1 is predictive for sepsis and acute kidney injury in surgical intensive care patients |
| Year | 2022 |
| PMID | 35922468 |
| Fungal Diseases involved | Sepsis |
| Associated Medical Condition | Acute kidney injury |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | The study is registered in the German Clinical Trials Register (trial code: DRKS00013584) and was approved by the local ethics committee (Justus-Liebig-University of Giessen, trial code: 86/18, amendment 3). Both the original study and this secondary analysis were performed in accordance with the Helsinki Declaration, and all methods and results are presented in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | sDLL1 |
| Biomarker Full Name | Soluble Delta-like protein 1 (sDLL1) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | The patient characteristics of the 80 included patients did not differ significantly regarding their age and sex (details are presented within the primary study20). 70% (n = 14) of the patients in the shock group, 75% (n = 15) in the CABG group, 60% (n = 12) in the MAS group, and 70% (n = 14) in the CTRL group were male. The ages (in years) of each group (expressed as the median [IQR]) were 69 [64–74] for septic shock, 70 [62–79] for CABG, 68 [54–70] for MAS, and 69 [66–74] for CTRL. The severity of sepsis was indicated by the sepsis-related organ failure assessment score (SOFA) score (SOFA at onset: 10.5 [10–12.5]; 24 h: 11.5 [8–13]; 72 h: 9 [5.5–14.5]), leading to an in-hospital-mortality rate of 35% (n = 7). Sepsis originated from intraabdominal infections in 60% (n = 12) of cases, whereas a pulmonary or urological source of infection was identified in 15% of cases (each n = 3) and a soft-tissue infection was detected in 10% (n = 2) of cases. MAS included Whipple’s procedure in 40% (n = 8) of patients, whereas open partial colectomy and esophagus resection were each performed in 20% (n = 4) of patients, and other types of MAS accounted for 20% (n = 4) of patients. |
| Cohort No. | 80 Patients |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Sepsis is a life-threatening complication of major abdominal and cardiovascular surgery and is associated with increased morbidity and mortality. Despite great research efforts regarding innovative strategies for the management of sepsis, its early detection and the rapid initiation of treatment remain the most effective approaches to reduce sepsis-associated mortality. Unfortunately, surgical patients are at risk for delayed diagnosis of sepsis because typical symptoms (e.g., fever, tachycardia, and altered mental status) are masked by postsurgical reactions. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | RayBiotech Life, Inc., Norcross, USA |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
