| DB ID | MyCo_2334 |
| Title | Inter-alpha inhibitor proteins in infants and decreased levels in neonatal sepsis |
| Year | 2003 |
| PMID | 12915817 |
| Fungal Diseases involved | Fungal sepsis |
| Associated Medical Condition | None |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | The Investigational Review Board for protection of human subjects approved all studies. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IaIp |
| Biomarker Full Name | Inter-a inhibitor protein (IaIp) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Rhode Island |
| Cohort | Umbilical cord and peripheral blood samples from 139 healthy nonseptic infants of different gestational ages were collected to establish the range of normal IaIp levels in neonates. Matching peripheral blood samples from 10 healthy infants and their mothers were also collected to investigate the correlation between both groups. |
| Cohort No. | 139 cases + 10 Controls |
| Age Group | 24-42 weeks |
| P Value | p<.0001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Bacterial/Fungal infection remains an important cause of morbidity and mortality in both term and preterm newborns. The pathogenesis of the neonatal predilection to infection is multifactorial and includes humoral, phagocytic, and cellular deficiencies. Early identification of septicemia is crucial for successful treatment and outcome in infected neonates. However, the symptoms are often nonspecific and begin unexpectedly; therefore, the clinical and laboratory investigation must start promptly. Antimicrobial therapy is usually initiated empirically before the results of bacteriological tests are available. Reliable and accurate markers that identify infants with neonatal sepsis are needed to reduce unnecessary use of antibiotics and the risk of emerging bacterial/fungal resistance in newborn nurseries. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
