| DB ID | MyCo_2318 |
| Title | Periodontitis and Cytomegalovirus Associate With Atherosclerosis Among HIV Patients After 5 Years on ART |
| Year | 2020 |
| PMID | 32541382 |
| Fungal Diseases involved | Periodontitis |
| Associated Medical Condition | HIV-AIDS |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | Ethical approval for this study was obtained from Health Research Ethic Committee Faculty of Medicine Universitas Indonesia & Cipto Mangunkusumo Hospital (no: 133/UN2.FI/ETIK/2018). |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CRP |
| Biomarker Full Name | C-reactive protein |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Indonesia |
| Cohort | A comprehensive survey of clinical and immunological responses in 82 patients beginning ART in the outpatient HIV clinic of an inner city tertiary hospital (Cipto Mangunkusumo Hospital, Jakarta, Indonesia) with ,200 CD4 T cells/mL.15 A subset of 32 HIV-infected patients attended a 5-year follow-up. Other patients could not be recalled because of moves to different health facilities, changed phone numbers and/or home addresses, refusal to participate, or AIDS-related death. Thirty-two healthy controls were recruited from hospital staff. We confirmed that they were matched groupwise with the patients by age and gender. |
| Cohort No. | 82 Patients |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Periodontitis is an inflammatory condition initiated by gingivitis, and causing progressive destruction of alveolar bone leading to tooth loss. Several studies have linked cardiovascular disease (CVD) with oral inflammation and periodontitis in the general population. For example; periodontitis was linked with myocardial infarction in 1989, and periodontitis associates with greater carotid intima-media thickness (cIMT) and impaired flow-mediated dilatation. Moreover CVD and periodontitis share predisposing factors, such as age, low socioeconomic and educational status, poor oral hygiene, smoking habits, and inflammatory genotypes. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
