| DB ID | MyCo_2317 |
| Title | Rapid decrease of anti-beta-glucan antibody as an indicator for early diagnosis of carinii pneumonitis and deep mycotic infections following immunosuppressive therapy in antineutrophil cytoplasmic antibody-associated vasculitis |
| Year | 2009 |
| PMID | 19190977 |
| Fungal Diseases involved | Carinii Pneumonitis |
| Associated Medical Condition | Pneumonia |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | anti-β-glucan |
| Biomarker Full Name | anti-β-glucan |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | Japan |
| Cohort | Twenty two healthy adults and 38 patients with AAV took part in the study. |
| Cohort No. | 60 |
| Age Group | None |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Some patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) achieve a good outcome after immunosuppressive treatment consisting mainly of administration of corticosteroids and immunosuppressants; however, the mortality rate is high due to infection. It is therefore important to find an effective treatment for infection in AAV patients. Postmortem examination of four patients out of a total of 60 patients with AAV who had received immunosuppressive therapy showed mycosis (aspergillosis or cryptococcosis). This indicated the necessity for early diagnosis of deep mycosis and carinii pneumonitis infection. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA KIT (Nunc 442404, F96 Maxisorp, Rochester,NY, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
