| DB ID | MyCo_2314 |
| Title | Advanced baseline immunosuppression is associated with elevated levels of plasma markers of fungal translocation and inflammation in long-term treated HIV-infected Tanzanians |
| Year | 2021 |
| PMID | 34446039 |
| Fungal Diseases involved | Fungal translocation and inflammation |
| Associated Medical Condition | HIV-AIDS |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | Ethical approval was obtained from Muhimbili University of Health and Allied Sciences (MUHAS) Senate Research and Publications Committee (SRPC) (Ref. No. 2016-12-07/AEC/Vol.XI/325), National Institute for Medical Research (NIMR), in Tanzania (NIMR/HQ/R.8a/Vol.IX/2373), and Ethics Committee for Epidemiological and General Research at the Faculty of Life Science, Kumamoto University (Ref. No. 1265). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Tanzania |
| Cohort | A total of 155 HIV-infected adults between January and August, 2018 from two care and treatment clinics in Dar es Salaam, Tanzania were recruited. Of these, 115 were patients that were initiated on treatment at advanced HIV disease and on stable long term ART with evidence of virological suppression (VL < 40 copies/ml) within 2–3 years of recruitment for the study. The rest (n = 40) were untreated newly diagnosed HIV-infected patients. All patients were conveniently enrolled into the study and their demographics and clinical data were collected using a structured questionnaire. Patients with symptoms of acute bacterial, parasite or viral infections were excluded from the study. Prior to enrolment to the study, a written informed consent was obtained from each patient. |
| Cohort No. | 115 Patients and 40 Control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA- Quickdetect Biovision CA USA |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
