| DB ID | MyCo_2311 |
| Title | Clinical significance of serum hepcidin-25 levels in predicting invasive fungal disease in patients after transplantation |
| Year | 2013 |
| PMID | 23852902 |
| Fungal Diseases involved | Invasive fungal infection |
| Associated Medical Condition | Transplantation |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | The study group was comprised of 57 consecutive patients (31 males and 26 females, mean age 49 (25-65) years) at Sichuan Academy of Medical Science and Sichuan Provincial People’ Hospital from October 2009 to January 2010. There were 27 patients with haematologic tumors suffering autologous or allogeneic SCT, 18 patients undergoing liver transplantation and 12 patients experiencing kidney transplantation. The normal control group was composed of 50 healthy volunteers that did not present anemia or inflammation. All the patients provided their written informed consent. |
| Cohort No. | 57 |
| Age Group | 25-65 |
| P Value | p<0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Tumor has been the leading killer of human health. Transplantation has been widely performed as a potentially curative treatment for intractable tumor malignancies with conventional chemotherapy. However, despite recent advances in the treatment of infectious disease and conditioning regimens for transplantation, treatment-related complications remain a major problem. Therefore, it is particularly important to identify a good biomarker that can predict treatment-related complications before transplantation and monitor dynamic drift. A recently accumulated body of evidence suggests that iron overload is associated with adverse clinical outcome. Other studies have shown that pretransplantation iron overload in autologous or allogeneic hematopoietic stem cell transplantation (SCT) was a risk factor associated with posttransplant complications, such as mucositis, bacterial, fungal infection, and hepatic veno-occlusive disease (VOD). Invasive fungal diseases (IFD) are a major cause of morbidity and mortality in patients with transplantation. Their incidence has risen dramatically in recent years. The diagnosis of IFDs remains difficult, even if the European Organization for the Research and Treatment of Cancer (EORTC)/Mycosis Study Group (MSG) criteria are applied for study purposes to classify the likelihood of these infections. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA kit (DRG, Marburg, Germany) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
