| DB ID | MyCo_2175 |
| Title | Comparison of pleural effusion features and biomarkers between talaromycosis and tuberculosis in non-human immunodeficiency virus-infected patients |
| Year | 2019 |
| PMID | 31455239 |
| Fungal Diseases involved | Talaromycosis |
| Associated Medical Condition | None |
| Genus | Talaromyces |
| Species | marneffei |
| Organism | Talaromyces marneffei |
| Ethical Statement | This study was approved by the Ethical Review Commit- tee of the First Affiliated Hospital of Guangxi Medical Uni- versity (2018.KY-E-071). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Pleural fluid |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IFN-γ |
| Biomarker Full Name | Interferon gamma |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | This study was an ambi-spective cohort study. We screened for talaromycosis in non-HIV-infected patients retrospect- ively from January 1, 2003 and prospectively from January 1, 2013 to May 31, 2017 at the First Affiliated Hospital of Guangxi Medical University, China, which is a 2750-bed tertiary referral center. We enrolled 19 cases each of TMPE and TPE from Guangxi, China. Patients’ clinical records, pleural effusion tests, biomarker test results, and receiver operating characteristic curves were analyzed. |
| Cohort No. | 19 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | The dimorphic fungus Talaromyces (previously Penicil- lium) marneffei causes a life-threatening mycosis, talaromy- cosis (previously penicilliosis), in immunocompromised persons living in or traveling from Southeast Asia, China, and India. An increasing number of cases with talaro- mycosis have been reported among non-human immuno- deficiency virus (HIV)-infected patients in recent years. Disseminated talaromycosis in non-HIV-infected pa- tients can infringe on the serous cavity to cause serous effusions, especially pleural effusions (talaromycosis pleural effusions [TMPEs]), which frequently went unrecognized previously. The difficulties and challenges in diagnosing TMPE in non-HIV-infected patients might be related to the rarity of clinical studies regarding TMPE, the non-spe- cificity of its clinical manifestations, low positivity rate of pleural effusion culture in the early stage of the disease, and misdiagnosis as other types of pleural effusion. Thus, guidelines for the diagnosis of pleural effusions caused by talaromycosis have not been established, and the diagnosis of TMPE remains challenging. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | enzyme-linked immunosorbent assay (ELISA) kits (Cusabio, Wuhan, China) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
