| DB ID | MyCo_2167 |
| Title | Neonatal T cells in an adult lung environment are competent to resolve Pneumocystis carinii pneumonia |
| Year | 2001 |
| PMID | 11313412 |
| Fungal Diseases involved | Pneumocystis carinii pneumonia |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | carinii |
| Organism | Pneumocystis carinii |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Extracted cell supernatant |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | TNF-α |
| Biomarker Full Name | Tumor Necrosis Factor alpha |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Five- to 6-wk-old BALB/c SCID and BALB/c mice were purchased from the National Cancer Institute (NCI). Mice were maintained at the Veteri-nary Medical Unit (VMU) of the Veterans Administration Medical Center (VAMC) under pathogen-free conditions. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis carinii is an opportunistic fungal pathogen that affects predominantly immunocompromised hosts in- cluding those with AIDS. P. carinii pneumonia (PCP)3 remains the most frequently reported serious opportunistic infec- tion in AIDS patients and the second highest cause of mortality among persons with AIDS in the U.S., despite the availability of effective chemoprophylaxis. Primary P. carinii infection is not common because immunocompetent individuals develop Ab to P. carinii by 2–3 years of age. Recently, it has been reported that there is a relatively high incidence of P. carinii infection in au-topsy specimens of children who die from sudden infant death syndrome. Although this does not necessarily indicate that PCP is a factor in sudden infant death syndrome it may reflect the fact that children frequently carry subclinical P. carinii infection. How- ever, very young patients with AIDS suffer a more fulminate course of PCP than older children with AIDS. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | sandwich ELISA kit (PharMingen), Ribo-Quant in vitro transcription and RPA kits (PharMingen) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
