MycoBiomDB – Record Details (MyCo_2164)

Biomarker Record Details

Database ID: MyCo_2164
DB IDMyCo_2164
TitleLung surfactant protein D (SP-D) response and regulation during acute and chronic lung injury
Year2013
PMID23435873
Fungal Diseases involvedPneumocystis carinii pneumonia
Associated Medical ConditionChronic Lung Injury
GenusPneumocystis
Speciescarinii
OrganismPneumocystis carinii
Ethical StatementThe Institutional Animal Care and Use Committees of the University of Pennsylvania and the Danish National Council for Animal Testing have approved the procedures for the use of mice. Thus, the authors declare that the experiments comply with the current laws of the country in which they were performed.
Site of InfectionLungs
Opportunistic invasiveOpportunistic
Sample typeBody fluid
Sample sourceSerum
Host GroupAnimal
Host Common nameMice
Host Scientific nameMus musculus
Biomarker NameSP-D
Biomarker Full NameSurfactant protein D
Biomarker TypeDiagnostic
BiomoleculeProtein
Geographical LocationUSA
CohortFemale virgin Balb/C mice (Taconic, Denmark), C57/BL6 mice (Charles River Laboratories, Wilmington, MA, USA), and Swiss Black wild-type mice (Taconic, Inc., Germantown, NY, USA) were housed at local animal facilities under controlled conditions, and the national animal welfare committees approved the studies ahead of performance.
Cohort No.None
Age GroupNone
P ValueNone
SensitivityNone
SpecificityNone
Positive Predictive ValueNone
MICNone
Fold ChangeNone
PathwayNone
Disease Introduction MechanismNone
TechniqueELISA
Analysis MethodELISA Based
ELISA kitsNone
Assay DataNone
Validation Techniques usedELISA,Immunohistochemistry
Up Regulation Down RegulationIncrease
Sequence DataNone
External LinkNone