| DB ID | MyCo_2124 |
| Title | Functional and phenotypic evaluation of eosinophils from patients with the acute form of paracoccidioidomycosis |
| Year | 2017 |
| PMID | 28489854 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | All study procedures were performed after informed consent, in accordance with standards established by the Committee of Ethics in Research School of Medical Sciences, UNICAMP (No 449/2008). Written informed consent was obtained from all participating subjects or their parents/guardians (on behalf of child participant). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TLR2+ |
| Biomarker Full Name | TLR2+ |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Here included 15 patients with the acute/juvenile form of PCM evaluated at a Pediatrics clinics at the University of Campinas, São Paulo, Brazil. The diagnosis was established by direct exam-ination and/or serology (double immunodiffusion test). The control group was composed of 11 healthy individuals with a maximum age of 35 years old. |
| Cohort No. | 15 patients and 11 control |
| Age Group | <35 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a systemic mycosis caused by dimorphic fungi of the Para- coccidioidesgenus. It is the most prevalent systemic mycosis of Latin America and, in Brazil, it is the leading cause of death among immunocompetent patients. PCM is caused by inhalation of environment Paracoccidioides conidia. The fungus may remain latent in tissues for years, without any clinical manifestation. Depending on the inocu-lum or host immune response, the disease may develop into two clinical forms: the acute/sub- acute form, which affects young adults and children, or the chronic form, which affects older adults. The acute/subacute or juvenile form comprises 10% of all cases. It is the most severe form of PCM, characterized by diffuse lymph node involvement, hepatosplenomegaly and bone marrow dysfunction. It may also affect skin and bones. Young patients of both genders are equally affected. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit R&D Systems (Minneapolis, MN, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
