| DB ID | MyCo_2083 |
| Title | Serum proteins and fractions, HDL-cholesterol and total IgG and IgE levels in cases of acute and chronic paracoccidioidomycosis |
| Year | 2009 |
| PMID | 19684969 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | The study had been approved by the Internal Scientific Commission and Research Bioethics Committee of Londrina State University (Londrina, PR, Brazil) and by the Research Ethics Committee of the Adolfo Lutz Institution (CEPIAL). |
| Site of Infection | Multiple organs |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IgE |
| Biomarker Full Name | Immunoglobulin E |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Serum samples from 30 chronic PCM patients (ranging from 33 to 82 years of age; all females) with unifocal or multifocal disease, who were attended at Londrina State University Clinical Hospital (Londrina, PR, Brazil), and 12 acute PCM patients (ranging from 11 to 23 years of age; seven females and five males) from the Mycosis Immunodiagnostic Laboratory, Immunology Section, Adolfo Lutz Institute, São Paulo, SP, Brazil, were used. |
| Cohort No. | 42 |
| Age Group | 33-82 and 11-24 |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis. It is considered to be one of the most common systemic mycoses in Latin America, and Brazil has the greatest number of cases10. PCM disease presents two clinically distinct forms: the acute or juvenile form (AF) and chronic or adult form (CF). The AF is characterized by rapid clinical evolution with the involvement of multiple organs, while the CF, which accounts for more than 90% of the patients, progresses slowly and silently for years. The multifocal CF is more severe and involves skin, mucosa, lungs and lymph node manifestations. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, HDLC, Electrophoresis, Immunodiffusion |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
