| DB ID | MyCo_2079 |
| Title | Regulation of immune responses by T suppressor cells and by serum in chronic paracoccidioidomycosis |
| Year | 1988 |
| PMID | 2972392 |
| Fungal Diseases involved | Chronic Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | DTH response |
| Biomarker Full Name | Delayed-type hypersensitivity response |
| Biomarker Type | Diagnostic |
| Biomolecule | None |
| Geographical Location | USA |
| Cohort | Male adult BALB/cByJIMR mice 8 to 12 weeks old were used in these experiments. They were obtained from the breeding colony of the Institute for Medical Research (San Jose, CA). Mice were supplied with sterilized food (Wayne Lab-Blox, Allied Mills, Chicago, IL), sterilized bedding, and acidified water. |
| Cohort No. | None |
| Age Group | None |
| P Value | p<0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis is the most important systemic mycosis in Latin America. It is caused by the dimorphic fungus Paracoccidioides brasiliensis. In patients with chronic disseminated paracoccidioidomycosis, an impairment of cell-mediated immune responses has been reported. In contrast humoral responses, measured as antibodies to P. brasiliensis, develop to high titers. Indeed, quantitation of antibodies is of great value in the prognosis of the disease. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Depressed |
| Sequence Data | None |
| External Link | None |
