| DB ID | MyCo_2025 |
| Title | Purification of the 115-kilodalton exoantigen of Cryptococcus neoformans and its recognition by immune sera |
| Year | 1993 |
| PMID | 8432820 |
| Fungal Diseases involved | Cryptococcosis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | MAb 7C9 |
| Biomarker Full Name | Monoclonal antibody 7C9 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | UK |
| Cohort | Sera from patients with confirmed cryptococcosis and known latex agglutination titers were obtained from the Mycology Department, Public Health Laboratory, Colindale, England (n=14). Controls consisted of 10 sera from healthy laboratory personnel. |
| Cohort No. | 14 Patients and 10 control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcus neoformans is the causative agent of cryp- tococcosis, a disease typified by an initial pulmonary infec- tion which can disseminate to produce an ultimately fatal form ofmeningitis. The disease has become an important infection in individuals suffering from AIDS and is now recognizedas the fourth most common life-threatening infection in this patient group. The diagnosis of the disease relies either on the isolation of the yeast or on the detection of capsular polysaccharide via the latex agglutination test with either cerebrospinal fluid or serum. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, Substrate SDS-PAGE |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
