| DB ID | MyCo_2023 |
| Title | Serum matrix metalloproteinase-2 levels indicate blood-CSF barrier damage in patients with infectious meningitis |
| Year | 2008 |
| PMID | 18185989 |
| Fungal Diseases involved | Mycotic Infectious Meningitis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neohormans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | MMP-2/gelatinase A |
| Biomarker Full Name | Matrix metalloproteinase-2 (MMP-2/gelatinase A) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Japan |
| Cohort | Serum and CSF samples were obtained from 40 patients with infectious meningitis who required CSF examination at Kitasato University Hospital and cooperating hospitals. The clinical diagnosis included 25 patients with viral meningitis (ten herpes simplex, ten varicella zoster, three measles and two mumps), who had been diagnosed by having elevated levels of the respective antibodies in the CSF; five patients with mycotic menin- gitis (all Cryptococcus neohormans); and ten patients with bacterial meningitis (four Streptococcus pneumoniae, four Haemophilus influenzae, two Pseudomonas aeruginozae), who had been diagnosed by CSF culture. |
| Cohort No. | 40 |
| Age Group | None |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (COBAS-MIRA; Roche-Diagnostic, Basel, Switzerland), ELISA Kit (HITACHI-7150; Hitachi Co., Tokyo, Japan), ELISA Kit (CAPPEL, Durham, NC, USA), ELISA Kit (Fuji Chemical Industries, Toyama, Japan) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
