| DB ID | MyCo_1993 |
| Title | Activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans |
| Year | 2001 |
| PMID | 11119508 |
| Fungal Diseases involved | Cryptococcus neoformans infection |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | All experimental protocols were approved by the Ethics Review Committee for Animal Experimentation of the university, University of the Ryukyus, Okinawa, Japan. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted cell supernatant |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | IFNγ |
| Biomarker Full Name | Interferon gamma |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Japan |
| Cohort | Breeding pairs of CD4-deficient (CD4KO) mice on a C57BL/6 back- ground were obtained from Jackson Laboratory (Bar Harbor, Maine). V 14 NKT-cell-deficient (NKT-KO) mice were established by targeted deletion of the J 281 gene segment (24) and backcrossed eight times with C57BL/6 mice. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | enzyme-linked immunosorbent assay (ELISA) Kit (Endogen, Inc., Cambridge, Mass.) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
