| DB ID | MyCo_1975 |
| Title | Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice |
| Year | 2020 |
| PMID | 33106296 |
| Fungal Diseases involved | Pulmonary coccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Coccidioides |
| Species | immitis |
| Organism | Coccidioides immitis |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | Th1 |
| Biomarker Full Name | Th1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Female BALB/c/HeJ mice were purchased from Jackson Laboratories, and BALB/c/AnNCr females were purchased from Charles River, both at 6 to 8 weeks of age. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Coccidioidomycosis, one of the endemic mycoses in the United States, has been increasing in incidence in both Arizona and California in recent years. It is caused by two closely related species, Coccidioides immitis and Coccidioides posadasii, which are thermally dimorphic fungi that cause the same clinical syndromes, pathol-ogy, and immune responses in humans and are distinguishable only by DNA analysis. There is a report of differences in how mice respond to the two species, but only one isolate of each species was studied, so one cannot tell if those differences were characteristic of the species or of the individual isolates tested. Both species live in alkaline desert soil as molds that produce arthroconidia (spores). When their hyphae are disturbed, arthroconidia are aerosolized and can be inhaled by a mammalian host. Under the influence of temperature and partial CO2 pressure (pCO2), arthroconidia transform into spherules. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
