| DB ID | MyCo_1927 |
| Title | Elevated serum level of progranulin is associated with increased mortality in critically ill patients with candidemia |
| Year | 2024 |
| PMID | 38246573 |
| Fungal Diseases involved | Candidemia |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | This prospective, multicenter study was performed in intensive care units (ICUs) at two university hospitals (The First Af liated Hospital of Chongqing Medical University and The Second Af liated Hospital of Chongqing Medical University) from 04/2016 to 06/ 2023. This study (ethics review number 2015-0302) received full approval from the local Institutional Research Review Committee, and informed consent was obtained from all participants. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | PGRN |
| Biomarker Full Name | Progranulin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | A retrospective discovery cohort (62 patients) and a validation cohort (70 patients) were enrolled. Blood was collected on day of rst blood culture positivity for C. albicans, and serum PGRN levels were then measured. |
| Cohort No. | 62 Patients and 70 control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candidemia, which constitutes 50e70% of invasive Candida infections, is a life-threatening Candida bloodstream infection that is associated with high mortality and substantial healthcare costs. Candida albicans remains the most frequent etiology of candidemia. The incidence of candidemia is increasing due to the use of invasive medical instruments (including central venous catheter, total parental nutrition, drainage tube, mechanical ventilation, tracheal intubation, indwelling gastric tube and urinary catheter) and immunosuppressive drugs. Moreover, the recent COVID-19 pandemic has changed the landscape of candidemia epidemiology, and has led to an increase in the incidence and mortality of candidemia, even in previously immunocompetent populations who suffer from viral disease. Therefore, it is important to develop riskclassi cation tools to assist with timely interventions that might mitigate exacerbation and improve survival in the candidemia patients. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | enzyme-linked immunosorbent assay kit (Catalog# DPGRN0, R&D systems). |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
