| DB ID | MyCo_1885 |
| Title | High serum laminin concentrations in patients with Candida sepsis |
| Year | 1999 |
| PMID | 10583445 |
| Fungal Diseases involved | Candida sepsis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | The study was performed 1996–98 at six intensive care units of the University Hospital of Vienna, a 2000 bed referral hospital, and had been approved by the institutional review board (University of Vienna, Vienna, Austria). |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Laminin |
| Biomarker Full Name | Laminin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Austria |
| Cohort | The study was performed 1996–98 at six intensive care units of the University Hospital of Vienna, a 2000 bed referral hospital, and had been approved by the institutional review board (University of Vienna, Vienna, Austria). Thirty-two patients and 20 controls were included after giving their informed consent. Blood cultures were drawn as soon as the patients developed fever and/or other signs and symptoms of sepsis. |
| Cohort No. | 32 patients and 20 controls |
| Age Group | 18–81 |
| P Value | p<0.01 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Disseminated candidiasis and Candida sepsis are major causes of morbidity and mortality in hospitalized patients. The increasing frequency rate of serious Candida hospital infections has multifactorial causes, including increasing usage of intravascular catheters, broad-spectrum antibiotics, extensive surgery and immunosuppression for neoplastic disease or allograft preservation. Candida albicans is not a mere passive participant in the infectious process, and a hypothetical set of virulence factors has been proposed and supported by various studies. These include the production of secreted hydrolytic enzymes, dimorphic transition (morphogenetic conversion from budding yeast to the filamentous growth form or hyphae), antigenic variability, the ability to switch between different cell phenotypes, adhesion to inert and biological substrates, and immunomodulation of host defence mechanisms. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA (Takara Biomedicals, TakaraShuzo, Shiga, Japan) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
