| DB ID | MyCo_1818 |
| Title | Alterations of serum cytokine levels and their relation with inflammatory markers in candidemia |
| Year | 2015 |
| PMID | 25627661 |
| Fungal Diseases involved | Candidemia |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | The study was approved by Uludag University, Faculty of Medicine, Ethics Board, and all patients and control subjects enrolled in the study were informed about the study and provided their consent. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-17 |
| Biomarker Full Name | Interleukin-17 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Turkey |
| Cohort | A total of 64 patients with candidemia, including 50 patients with blood cultures that yielded Candida spp. alone and 14 patients in which bacteria and Candida spp. (polymicrobial sepsis group) were obtained in blood cultures, were studied in adult clinics of the Uludag University, Health Sciences Center between May 1, 2011, and February 28, 2013. Thirty patients with bacteremia and 27 patients without any infections (20 healthy people without comorbidity who had been admitted to the center for blood transfusions as donor candidates and 7 people who had been hospitalized for elective surgery) were enrolled in the study to complete the comparative model. Venous blood samples obtained from patients and healthy control subjects were stored at −80◦C. |
| Cohort No. | 121 |
| Age Group | None |
| P Value | P=0.024 |
| Sensitivity | 0.38 |
| Specificity | 0.966 |
| Positive Predictive Value | 0.95 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | In the last 25 years, the incidences of fungal infections have dramatically increased, for example, 19% of the infections documented in the intensive care units (ICU) were caused by fungi. More than 80% of the fungi that cause nosocomial infections are Candida species. Based on the data obtained from the National Nosocomial Infections Surveillance (NNIS), USA, a 1.8–5.9-fold increase was detected in bloodstream infections caused by the Candida species between 1980 and 1990 depending on the hospital type. Another analysis of the data obtained within the same period revealed that the Candida species accounted for 85.6% of all nosocomial fungal infections. In a more recent study, the mortality rate observed in adults attributed to candidemia was found to be 14.5% and mortality in cases of invasive candidiasis may reach 40–50%. Because delayed administration of the antifungal therapy is associated with an increase in mortality, early diagnosis and therapy is crucial for preventing invasive candidiasis. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (human TGF-β1, Boster Immunoleader R ; human IL- 23, Omni Kine R ; human IL-17, Boster Immunoleader R ; human TNF-α, Assay Max R ; human IL-1 β, Boster Immunoleader R ; human IL-10, Boster Immunoleader), ELISA kit (BRAHMS PCT) |
| Assay Data | None |
| Validation Techniques used | ELISA, Nephelometric method |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
