MycoBiomDB – Record Details (MyCo_1799)

Biomarker Record Details

Database ID: MyCo_1799
DB IDMyCo_1799
TitlePrimary role for CD4(+) T lymphocytes in recovery from oropharyngeal candidiasis
Year2002
PMID11796605
Fungal Diseases involvedOropharyngeal candidiasis
Associated Medical ConditionAIDS
GenusCandida
Speciesalbicans
OrganismCandida albicans
Ethical StatementAnimal experiments were approved by the Animal Experimentation Ethics Committee of the University of Queensland and were carried out in accordance with the National Health and Medical Research Council’s Australian Code of Practice for the Care and Use of Animals for Scientific Purposes, 1997.
Site of InfectionNone
Opportunistic invasiveOpportunistic
Sample typeBody fluid
Sample sourceCervical Lymph
Host GroupAnimal
Host Common nameMice
Host Scientific nameMus musculus
Biomarker NameIFN-γ
Biomarker Full NameInterferon gamma
Biomarker TypeDiagnostic
BiomoleculeProtein
Geographical LocationAustralia
CohortSpecific-pathogen-free BALB/c and CBA/CaH female nude mice, their heterozygous littermates, and euthymic controls, 6 to 8 weeks of age, were purchased from the Animal Resources Centre, Perth, or from the Walter and Eliza Hall Institute, Melbourne, Australia.
Cohort No.None
Age Group6-8 Weeks
P ValueNone
SensitivityNone
SpecificityNone
Positive Predictive ValueNone
MICNone
Fold ChangeNone
PathwayNone
Disease Introduction MechanismOral candidiasis is a predominant feature in patients suffering from human immunodeficiency virus (HIV) and AIDS, and these patients, as well as those with chronic mucocutaneous candidiasis, commonly exhibit defects in cell mediated immunity.
TechniqueELISA
Analysis MethodELISA Based
ELISA kitsNone
Assay DataNone
Validation Techniques usedELISA, FACS,RT-PCR
Up Regulation Down RegulationIncrease
Sequence DataNone
External LinkNone