| DB ID | MyCo_1788 |
| Title | Burn-associated Candida albicans infection caused by CD30+ type 2 T cells |
| Year | 1998 |
| PMID | 9620665 |
| Fungal Diseases involved | Candida albicans infection |
| Associated Medical Condition | Burn injury |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Peripheral Blood Lymphocytes (PBL) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD30+ |
| Biomarker Full Name | CD30+ |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | PBLs from 21 thermally injured patients (4 females and 17 males), admitted to the Shriners Burns Hospital for Children in Galveston, were utilized in this study (see Table 1). These patients were either under 10 years old (13 patients) or 10–17 years old (8 patients). PBLs from nine healthy donors (4 children, 5–9 years old; 5 adults, 26–42 years old) were used as controls. The thermally injured patients had flame burns that covered total body surface area (TBSA) of less than 40% (3 patients; 25% average TBSA) and over 40% (18 patients; 63% average TBSA). After hospitalization, all of these patients received a standard treatment procedure. |
| Cohort No. | 21 |
| Age Group | Oct-17 |
| P Value | p<0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | The mortality of thermally injured patients is largely associated with infections. Thermally injured patients with septic infections have displayed survival rates as low as 20%, despite intensive medical care for the skin damage, abnormal metabolism, and wound infections. Candida albicans has been reported as a severe pathogen in thermally injured patients, but in healthy individuals it causes less severe problems. C. albicans is a common member of the normal flora in humans, but in immunologically compromised patients this fungus causes disseminated mucosal, cutaneous, or systemic candidiasis. Spebar and Pruitt reported that 21% of burned patients developed invasive Candida sepsis, and over 90% of these infected patients died. The major underlying etiology for opportunistic C. albicans infections in thermally injured patients is the immunological abnormalities associated with the thermal injury. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
