| DB ID | MyCo_1719 |
| Title | Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis |
| Year | 2010 |
| PMID | 20008537 |
| Fungal Diseases involved | Aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | Informed consent for blood collection was obtained from all individuals. The study was approved by the local ethics committee. Research Institute for Internal Medicine, Rikshospitalet, N-0027, Oslo, Norway. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | RANTES (CCL5) |
| Biomarker Full Name | RANTES (CCL5) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Norway |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillosis is the most common mold infection worldwide, and Aspergillus fumigatus accounts for more than 90% of the cases. In contrast to most human pathogens, which are encountered infrequently, A. fumigatus spores are inhaled on a daily basis, and occasionally, exposure to large numbers of conidia can occur. The first-line host defense against Aspergillus infection is based on innate immunity mediated by monocytes/macrophages and neutrophils. The adaptive immune system responds to a pathogen only after it has been recognized by the innate immune system. While inadequate immune responses may predispose to invasive dis- ease, overly robust responses can result in immune mediated inflammatory tissue damage. Thus, imbalanced immune responses to A. fumigatus may result in a spectrum of human disease states ranging from allergic bronchopulmonary aspergillosis to invasive aspergillosis in the immunocompromised host. Despite better diagnostic tools and therapeutic advances, the infection is difficult to diagnose and treat, and the outcome of invasive aspergillosis is often fatal. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, Flow Cytometry |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
