| DB ID | MyCo_1702 |
| Title | Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis |
| Year | 2017 |
| PMID | 28487045 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | This study was approved by the Research Ethics Board of the University Health Network (UHN), University of Toronto. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Pentraxin 3 |
| Biomarker Full Name | Pentraxin 3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Canada |
| Cohort | BAL samples, collected from LTRs at UHN between December, 2008 and June, 2014 for clinical purposes, were analyzed. Surveillance bronchoscopies are performed at two and six weeks, and three, six, nine, 12, and 18 months post lung transplantation. In addition, diagnostic bronchoscopies were also performed when infection or rejection was suspected in LTRs. Healthy control samples were kindly provided by Dr. Durairaj L from University of Iowa. These BAL samples were taken from healthy subjects who underwent bronchoscopy for research purposes. The samples were stored and transferred at -80 degrees C. |
| Cohort No. | 151 Patients + 9 control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus species are the most common cause of invasive fungal infection (IFI) in lung transplant recipients (LTRs). A range of clinical syndromes can be caused by Aspergillus spp. in LTRs, including colonization of airways, tracheobronchial (TB) infection, anastomotic infection, pulmonary disease and disseminated disease 3. LTRs with Aspergillus colonization (Asp col) of the airways are 11 times more likely to develop invasive disease in the first six months post-transplant. To decrease the incidence of invasive aspergillosis (IA), 60% of lung transplant programs have adopted a universal antifungal prophylaxis approach post-transplantation. Unfortunately, this approach carries an increased risk of toxicity, drug interactions, and cost, without evidence of any benefit. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (R&D, Minneapolis, MN, cat. DY1826) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
