| DB ID | MyCo_1692 |
| Title | Monoclonal antibodies to hyphal exoantigens derived from the opportunistic pathogen Aspergillus terreus |
| Year | 2011 |
| PMID | 21734068 |
| Fungal Diseases involved | Aspergillus terreus infection |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | terreus |
| Organism | Aspergillus terreus |
| Ethical Statement | The animal protocol was approved by the National Institute for Occupational Safety and Health (NIOSH) Animal Care and Use Committee. The NIOSH animal facility is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC). |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | MAbs 13E11 |
| Biomarker Full Name | Monoclonal antibodies-MAbs 13E11 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Monongalia County |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus terreus is a filamentous fungus associated with organic detritus decay in the soil rhizosphere. A. terreus has been reported as a human pathogen and can cause superficial, cutaneous, and subcutaneous mycoses that affect the nail bed, outer ear canal, and skin. More recently, A. terreus has been associated with postoperative osteomyelitis, endophthalmitis, and peritonitis, and the species has been identified as an emerging opportunistic pathogen in immunocompromised populations. Knowledge of A. terreus pathogenesis is limited; however, the species is thermotolerant and produces aleurioconidia that may provide an advantage in dissemination. A. terreus also produces terrelysin, a hemolytic protein that has been recently reported as a putative virulence factor. The species also produces secondary metabolites that may have toxic effects on host cells and may help facilitate invasive disease. Species-specific diagnosis of A. terreus opportunistic infections is clinically important due to this pathogen’s resistance to the primary antifungal therapeutic amphotericin B. To date, the identification of A. terreus infections has challenged the most seasoned clinicians. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, WESTERN Blot, Proteomics |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
