| DB ID | MyCo_1661 |
| Title | Expression of the surface antigens of lymphocytes and the levels of cytokines in mice infected with Aspergillus fumigatus |
| Year | 2008 |
| PMID | 19736385 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | The animal experiments were conducted according to the “Guide for the Care and Use of Laboratory Animals” of the Gazi University School of Medicine. Local Ethical Committee, from which permissions were also obtained. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Cardiac Blood |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | IL-4 |
| Biomarker Full Name | Interleukin-4 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Turkey |
| Cohort | Twelve female BALB/c mice were used in this study. All mice were 6-8 weeks old. Animals were kept under standard laboratory conditions. |
| Cohort No. | 12 |
| Age Group | None |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus fumigatus (A. fumigatus), the most common cause of invasive aspergillosis, is an opportunistic fungus. A. fumigatus infections have also been associated with mortality in immunocompromised patients. The immune system is important for host defense, and host defense reactions against microorganisms are numerous and varied. Cell-mediated immunity and humoral immunity are the principle protective immune responses against fungal infections. Acquired immunity also plays significant roles in the fungus-host interaction. Nevertheless, nonspecific cellular immunity mediated by macrophages, neutrophils and natural killer (NK) cells may provide the main defences against fungi. Specific antibodies occur during fungal infections but the role of antibodies in protective immunity is unclear. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (Biosource, California, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA, Flow Cytometry |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
