| DB ID | MyCo_1602 |
| Title | The role of pentraxin3 in plasma and bronchoalveolar lavage fluid in COPD patients with invasive pulmonary aspergillosis |
| Year | 2021 |
| PMID | 34915889 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The study was approved by the Institutional Review Board of Changzhou first people’s Hospital (No.2019-020). Due to the retrospective nature of this study, verbal informed consent have been obtained form all participants through telephone follow-up. |
| Site of Infection | None |
| Opportunistic invasive | Invasive/Opportunistic |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | A total of 165 patients were included in the study, of whom 35 had confirmed or probable IPA. The remain-ing 130 patients served as controls. |
| Cohort No. | 165 patients and 130 control |
| Age Group | None |
| P Value | None |
| Sensitivity | 0.6 |
| Specificity | 0.938 |
| Positive Predictive Value | 0.897 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA) is a serious oppor-tunistic infection caused by Aspergillus spp. In recent years, the incidence of IPA has gradually increased in patients with chronic obstructive pulmonary disease (COPD). Current research suggests that the occurrence of pulmonary Aspergillus infection in patients with COPD is related to the long-term use of glucocorticoids and antibiotics. Patients with COPD and pulmonary invasive aspergillosis often present with atypical symp- toms and imaging. Therefore, the early diagnosis of these patients is difficult, and the fatality rate is high. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit (DPTX30, Quantikine Human Pentraxin 3 Immunoassay, R&D, Abingdon, UK). |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
