| DB ID | MyCo_1600 |
| Title | Comparing the diagnostic value of bronchoalveolar lavage fluid galactomannan, serum galactomannanan, and serum 1,3-β-d-glucan in non-neutropenic respiratory disease patients with invasive pulmonary aspergillosis |
| Year | 2021 |
| PMID | 33832082 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The study was approved by the Ethics Committee of Zhong Shan Hospital, Medical College of Xiamen University, and performed in compliance with the Declaration of Helsinki (2008). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | A total of 333 non-neutropenic patients suspected IPA were recruited from Xiamen University Zhong Shan hospital betwee January 2016 and February 2019. |
| Cohort No. | 333 |
| Age Group | 37-83 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA) is a type of respiratory infectious disease mainly caused by pulmonary Aspergillus invading the bronchial and vascular walls. IPA usually occurs in neutropenic patients accompanied by immune function damage, including organ transplantation and hematological malignancy; the incidence of IPA is closely related to the mortality of these diseases. However, IPA is increasing in non- neutropenic patients with chronic underlying diseases, such as chronic obstructive pulmonary disease (COPD) and diabetes mellitus. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | immunoenzymatic sandwich microplate assay (ELISA) Kit (Bio-Rad laboratories), Kinetic-turbidimetric LAL kit and microbial dynamic moni-toring system (ELX 808) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
