| DB ID | MyCo_1576 |
| Title | Invasive aspergillosis in allogeneic stem cell transplant recipients: increasing antigenemia is associated with progressive disease |
| Year | 2002 |
| PMID | 11880959 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Allogeneic stem cell transplant (SCT) |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomamman |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | We reviewed the medical records for all allogeneic SCT recipients who developed IA during the period from January 1995 through September 1998. All patients had undergone transplantation in the Bone Marrow Transplant Unit at Hoˆpital Saint-Louis (Paris, France). Diagnoses of IA were reviewed by the Hospital Aspergillus Study Group. Diagnoses were made on the basis of the findings of clinical charts, imaging studies (including CT scans), and mycological criteria. |
| Cohort No. | 37 |
| Age Group | None |
| P Value | p=.002 |
| Sensitivity | 0.44 |
| Specificity | 0.87 |
| Positive Predictive Value | 0.94 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) has become one of the leading infectious complications among allogeneic stem cell transplant (SCT) recipients, with a mortality rate of 80%. This dreadful prognosis is related to the severe and protracted immunosuppression experienced by these patients, as well as to the frequent delay in diagnosis and insufficient treatment efficiency and/or limiting toxicity of antifungal agents. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | Sandwich immunocapture ELISA Kit (Platelia Aspergillus; Bio-Rad) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
