| DB ID | MyCo_1573 |
| Title | Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK |
| Year | 2021 |
| PMID | 34338598 |
| Fungal Diseases involved | Aspergillus fumigatus infection |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | The protocol was approved by the Laboratory Animal Welfare and Ethics Committee (IACUC-13- 2016-002), Academy Military Medical Sciences, China. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | CR3 |
| Biomarker Full Name | Complement receptor 3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | C57BL/6 mice were obtained from the Animal Center of Academy of Military Medical Sciences. CR3−/- mice were purchased from the Nanjing Biomedical Researc Institute of Nanjing University. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillus fumigatus is a ubiquitous opportunistic pathogen with airborne conidia, which is small enough (diameter of 2–3 μm) to be inhaled into human airways and even deeply embedded into the lung alveoli. In the immunocompromised host, inhaled conidia could lead to induce a lethal invasive infection, and in some cases, even death. Previous studies on the interactions of A. fumigatus with host innate immune system mostly focused on professional immune cells, such as macrophages, neutrophils and monocytes; however, increasing number of studies indicated that lung epithelial cells, as the initial contact point between the airborne pollutant and the host, act not only as a physical barrier but also a critical player in the host innate immunity against A. fumigatus. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
