| DB ID | MyCo_1568 |
| Title | Early proinflammatory cytokines and C‐reactive protein trends as predictors of outcome in invasive Aspergillosis |
| Year | 2010 |
| PMID | 20879853 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | This study was approved by the Eu-ropean Organization for Research and Treatment of Cancer. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CRP |
| Biomarker Full Name | C-reactive protein |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Study patients were from the Global Comparative Aspergillosis Study (protocol 150–307), a multicenter randomized trial that compared the efficacy of vor- iconazole versus amphotericin B in the primary treatment of invasive aspergillosis. A total of 539 serum specimens serially collected from 119 patients enrolled in the clinical trial were available for analysis. |
| Cohort No. | 119 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis continues to be a leading cause of mortality and morbidity among patients treated for he- matological malignancies. The adverse outcomes associated with acquisition of the disease may in part be attributable to the compromised immune system of at-risk patients. Securing a firm diagnosis of invasive aspergillosis remains difficult. Management of invasive aspergillosis is complicated by the absence of appro-priate tools with which to assess progress and treatment response. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | sandwich enzyme-linked immunosorbent assay (ELISA) kits (Pelikine Compact; CLB) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
