| DB ID | MyCo_1525 |
| Title | Comparison of the Performance of Two Galactomannan Detection Tests: Platelia Aspergillus Ag and Aspergillus Galactomannan Ag Virclia Monotest |
| Year | 2022 |
| PMID | 35262395 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Macromolecule |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Madrid |
| Cohort | Overall, 327 samples (327 patients) were analyzed in a retrospective/prospective study performed in 3 hospitals in Madrid, comparing the determination results in serum or bronchoalveolar lavage of two techniques for galactomannan detection, namely, Platelia Aspergillus Ag (Bio- Rad) and Aspergillus galactomannan Ag Virclia Monotest (Vircell S.L.), following the manufacturer’s instructions. |
| Cohort No. | 327 Patients |
| Age Group | None |
| P Value | None |
| Sensitivity | 0.809 |
| Specificity | 1 |
| Positive Predictive Value | 1 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) is the second most common IFI, behind invasive candidiasis (IC); at present, the population at risk is composed not only of neutropenic patients but also of a growing group of cases with other comorbidities, including SARS-CoV-2 infection. The signs and symptoms of IA are often nonspecific. It is challenging to distinguish colonization from infection; blood cultures are practically always negative, and it is frequently difficult or impossible to perform invasive techniques in order to obtain proper samples. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA- Platelia Aspergillus Ag kit (Bio-Rad) , ELISA- Aspergillus galactomannan Ag Virclia Monotest (Vircell S.L.) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
