| DB ID | MyCo_1523 |
| Title | Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia |
| Year | 2020 |
| PMID | 32428065 |
| Fungal Diseases involved | Candidemia |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | This study was approved by the Ethics Committee of the West China Hospital, (The Ethics Committee of West China Hospital, Nº 75, 76). |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Anti-mannan -IgG |
| Biomarker Full Name | Anti-mannan -Immunoglobulin G |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | In total, there were 213 cases with neither colonization nor infections, 48 with Candida colonization and 40 with candidemia in our study. Among the cases with neither Candida colonization nor infections, 55 of them were healthy controls randomly selected from the health examination center of the West China hospital, 158 were hospitalized patients, of whom 13 had other bloodstream infections. The 13 patients included 4 with Staphylococcus spp., 2 with Enterobacteria spp., 1 with Enterococcus spp., 1 with Talaromyces (Penicillium) marneffei, and 5 with Cryptococcus spp. infection. None of them had neutropenia, recent or ongoing immunosuppressive therapy or antifungal therapy. |
| Cohort No. | 246 Patients + 55 Control |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | In total, there were 213 cases with neither colonization nor infections, 48 with Candida colonization and 40 with candidemia in our study. Among the cases with neither Candida colonization nor infections, 55 of them were healthy controls randomly selected from the health examination center of the West China hospital, 158 were hospitalized patients, of whom 13 had other bloodstream infections. The 13 patients included 4 with Staphylococcus spp., 2 with Enterobacteria spp., 1 with Enterococcus spp., 1 with Talaromyces (Penicillium) marneffei, and 5 with Cryptococcus spp. infection. None of them had neutropenia, recent or ongoing immunosuppressive therapy or antifungal therapy. |
| Technique | Immunological assay |
| Analysis Method | ELISA Based |
| ELISA kits | anti-mannan IgM and IgG ELISA assays Kit (Dynamiker Biotechnology, Tianjin, China) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
