| DB ID | MyCo_1517 |
| Title | Systematic fungal biomarker or polymerase chain reaction testing in lung transplant recipients: Retrospective analysis to optimize their use |
| Year | 2023 |
| PMID | 37608632 |
| Fungal Diseases involved | Pneumocystis jirovecii pneumonia |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | jirovecii |
| Organism | Pneumocystis jirovecii |
| Ethical Statement | This study was approved by Institutional Review Board Northwestern University, University Feinberg School of Medicine, Chicago, IL 60611, USA |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1,3-ß-D-glucan |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | After Institutional Review Board approval, we retrospectively collected all GM and PJ DFA or PCR performed on BAL; and all GM and BDG performed on serum from adults lung transplant recipients at our large academic center from January 2015 – July 20, 2022. Primary data was abstracted from the Northwestern Medicine Enterprise Data Warehouse and then manual chart review was used to inform clinical likelihood of infection. |
| Cohort No. | 236 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA, (1–3)-ß-D Dextran Test Elisa ,Pneumocystis jirovecii pneumonia PCR |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
