| DB ID | MyCo_1497 |
| Title | Absence of CD4+ T cells impairs host defence of mice infected with Fonsecaea pedrosoi |
| Year | 2006 |
| PMID | 17083615 |
| Fungal Diseases involved | Chromoblastomycosis |
| Associated Medical Condition | None |
| Genus | Fonsecaea |
| Species | pedrosoi |
| Organism | Fonsecaea pedrosoi |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted cell supernatant |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | DTH |
| Biomarker Full Name | Delayed-type hypersensitivity |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Female C57BL/6 CD4 and CD8-deficients and CD4 and CD8-sufficient mice ranging from 8 to 12 weeks old were purchased at the Isogenic Breeding Unit of the Department of Immunology, Biomedical Sci- ence Institute, University of Sa ˜o Paulo. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Chromoblastomycosis is a human chronic subcutaneous infection, beginning after inoculation trauma, caused by several dematiaceous fungi. These fungi are found in the soil and in decomposing plant matter. It occurs world- wide, but is more frequently observed in tropical countries such as Brazil. This mycosis is caused by several species of dematiaceus hyphomycetes: Fonsecaea pedrosoi, Phialophora verrucosa, Cladophialophora carrionni, and Rinocladiella aquaspersa. Clinically, chromoblasto- mycosis is characterized by the slow development of polymorphic skin lesions (nodules, verrucas, plaques and scar tissue). Inside the host, infectious propagules adhere to epithelial cells and differentiate into sclerotic forms, which effectively resist destruction by host effector cells and allow the establishment of chronic disease. The disease is usually insidious and the lesions increase slowly but progressively, not responding to the usual treatments and quite often reappearing. |
| Technique | Assay |
| Analysis Method | DTH footpad assay |
| ELISA kits | ELISA Kit (Becton Dickinson, Mountain View, CA, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA, DTH footpad assay |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
