| DB ID | MyCo_1433 |
| Title | Paracoccidioidomycosis due to P lutzii: The importance of neutrophil/lymphocyte ratio in the symptomatic and asymptomatic phases in severe cases |
| Year | 2021 |
| PMID | 33829534 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | lutzii |
| Organism | Paracoccidioides lutzii |
| Ethical Statement | This study was approved by the Research Ethics Committee of the Júlio Müller University Hospital, under number 3,285,959/2019, CAAE: 2 08640919.8.0000.5541. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CRP |
| Biomarker Full Name | C-reactive protein |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | This is a retrospective study of data obtained from medical re- cords of patients seen at the Systemic Mycoses Referral Center at the Júlio Muller University Hospital, in Cuiabá (MT), Brazil. All the patients treated for PCM by P lutzii between January/2017 and March/2020 were eligible for the study. The study included 44 patients. Age ranged from 19 to 76 years, with a mean (SD) of 48.54 (11.49) years. |
| Cohort No. | 44 |
| Age Group | 19-76 |
| P Value | p=0.002 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a neglected systemic mycosis considered endemic in Brazil, Colombia, Venezuela, Argentina, Ecuador, Paraguay and other countries in Latin America. It has a higher prevalence in South America, with Brazil being the main endemic focus of the disease with 80% of cases, followed by Colombia and Venezuela.1 It is a serious public health problem in Brazil, accounting for 50% of deaths caused by systemic mycoses. According to the number of admissions for PCM, there is an esti- mated incidence of 7.99 cases per 1000 hospital admissions, sur- passing other systemic mycoses such as coccidioidomycosis and histoplasmosis, in addition to presenting a pathogenic potential in immunocompetent hosts and being extremely disabling. It is also characterised by predominantly reaching socioeconomically vul- nerable populations, professionals who manage the soil in some way, rural workers, and professionals involved in civil construc- tion and extractive activities. It is known that smoking and alcohol consumption are considered risk factors for the development of the chronic form of the disease. In addition to the increase in the evident risk of tobacco for PCM, the direct pathogenic effects of smoking on the airways aggravates the clinical evolution and com- promises the diagnosis. |
| Technique | Assay |
| Analysis Method | CRP assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ESR count analysis, NLR count analysis, CRP assay |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
