| DB ID | MyCo_1423 |
| Title | Impact of biological sex on cryptococcal meningitis mortality in Uganda and South Africa |
| Year | 2021 |
| PMID | 33399865 |
| Fungal Diseases involved | Cryptococcal meningitis |
| Associated Medical Condition | HIV-AIDS |
| Genus | Cryptococcus |
| Species | spp. |
| Organism | Cryptococcus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Cerebrospinal fluid (CSF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Granzyme B |
| Biomarker Full Name | Granzyme B |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Uganda and South Africa |
| Cohort | We analyzed prospectively screened participants’ data from the Cryptococcal Optimal ART Timing trial (n = 226) (Clinical- Trials.gov: NCT01075152), Neurological Outcomes on ART study (n = 26), and the Adjunctive Sertraline for the Treat- ment of HIV-Associated Cryptococcal Meningitis pilot phase and trial (n = 725) (ClinicalTrials.gov: NCT01802385). |
| Cohort No. | 977 |
| Age Group | 32-36 |
| P Value | p<.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcal meningitis remains the second leading cause of mortality among HIV-infected persons. The greatest burden of cryptococcal meningitis is in sub-Saharan Africa where an esti- mated 73% of incident cases and 75% deaths occur. Despite this, important patient demographic information, such as bio- logical sex, is limited in sub-Saharan Africa. There have been at least five studies to evaluate biological sex in cryptococcal meningitis cohorts. Of these,four cohorts reported higher in- cidence of cryptococcal meningitis in men compared to women, but only two of these studies were from Africa. Mortalitydueto cryptococcal meningitis is not often reported by biological sex. However, one study based in China indicated that women had a slightly higher mortality of cryptococcal meningitis in their cohort. |
| Technique | Analytic |
| Analysis Method | Cox proportional hazards models analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Cox proportional hazards models analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
