| DB ID | MyCo_1366 |
| Title | Increased serum ferritin is associated with severity of orbital disease in COVID-19-associated rhino-orbito-cerebral mucormycosis: A quantitative analysis |
| Year | 2025 |
| PMID | 38990622 |
| Fungal Diseases involved | Rhino‑orbito‑cerebral Mucormycosis |
| Associated Medical Condition | COVID-19 |
| Genus | Rhizopus |
| Species | oryzae |
| Organism | Rhizopus oryzae |
| Ethical Statement | Institutional ethical committee clearance and informed consent were taken, King George Medical University, Lucknow, Uttar Pradesh, India. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Ferritin |
| Biomarker Full Name | Ferritin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | India |
| Cohort | Hundred (n) out of 155 treatment‑naive patients of COVID‑19 infection presenting with the signs and symptoms of rhino‑orbito‑cerebral mucormycosis were enrolled in study. |
| Cohort No. | 100 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Mucormycosis is a life threatening angioinvasive fungal disease. It is caused by fungus that belongs to the order Mucorales. Rhino orbito cerebral mucormycosis (ROCM) is the most common clinical type of mucormycosis. It is most commonly caused by Rhizopus oryzae. In the pre coronavirus disease (pre COVID) era, prevalence of mucormycosis in India was approximately 0.14 cases per 1000 population, which was about 80 times the prevalence in developed countries. But recently, there has been an unprecedented increase in incidence of ROCM in the setting of coronavirus disease 2019 (COVID 19) infection in India and elsewhere. In the second wave of COVID 19, India contributed to 81% of COVID 19–associated ROCM cases. The important risk factors predisposing to ROCM are concurrent COVID 19 infection, uncontrolled diabetes mellitus (DM) with or without ketoacidosis, iron overload, neutropenia, treated with corticosteroids/ immunomodulators, long standing oxygen therapy, and mechanical ventilation. |
| Technique | Immunological assay |
| Analysis Method | Chemiluminescence Immunoassay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Chemiluminescence immunoassay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
