| DB ID | MyCo_1319 |
| Title | Combination of sepsis biomarkers may indicate an invasive fungal infection in haematological patients |
| Year | 2019 |
| PMID | 30907674 |
| Fungal Diseases involved | Invasive fungal infection |
| Associated Medical Condition | Hematological patients |
| Genus | Candida |
| Species | cruzei |
| Organism | Candida cruzei |
| Ethical Statement | The study was approved by the Institutional Review Board and Ethics Committee. Adult patients hospitalized to receive chemotherapy for hematological malignancies or to receive treatment of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation having an episode of microbiologically proven bacterial/fungal infection were included in the study. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | PCT<1.25 ng/mL and CRP>120 mg/L |
| Biomarker Full Name | Procalcitonin<1.25 ng/mL and C-reactive protein>120 mg/L |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Belarus |
| Cohort | This prospective observational clinical study was performed in a large tertiary hematology and bone marrow transplantation center during the period from 2013 to 2018 years. During the period of 2013 2018 years there were totally 64 patients included in the study. The total number of patients with hematological neoplasms seen in the described units during the study period was 1246 patients, including 218 patients with fulfilled criteria of febrile neutropenia. Among them, 64 patients had an episode of microbiologically proven bacterial/fungal infection. |
| Cohort No. | 64 |
| Age Group | 34-51 |
| P Value | p<0.0001 |
| Sensitivity | 0.9 |
| Specificity | 0.929 |
| Positive Predictive Value | 39.9 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Infectious complications in immunocompromised patients with neutropenia or on long lasting immunosuppressive treatments are a serious issue. Invasive fungal infections (IFI) represent cases in which delayed or inappropriately targeted treatments can have fatal consequences. Today Aspergillus spp. and Candida spp. are the two most important genera accounting for about 95 % of all cases of IFIs (Tacke et al. 2014). The early diagnosis of IFI remains a complicated issue nowadays. |
| Technique | Analytic |
| Analysis Method | C-reactive protein (CRP), presepsin, procalcitonin (PCT) Test |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | C-reactive protein (CRP), presepsin, procalcitonin (PCT) Test |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
