| DB ID | MyCo_1268 |
| Title | New clinical algorithm including fungal biomarkers to better diagnose probable invasive pulmonary aspergillosis in ICU |
| Year | 2021 |
| PMID | 33683480 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The RESSIF network was approved by the Institut Pasteur institutional review board (IRB #2009-34). Approval of the "Commission Nationale de l’Informatique et des Libertés" was obtained, ensuring that patient’s data were kept and used according to French regulation. The BM-AspICU substudy was approved by the coordinating committee of RESSIF in April 2019. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | None |
| Sample source | None |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | The analysis of the aspergillosis records between January 2012 and December 2017 retrieved 35 patients over 18 years old with proven IPA and admitted to the ICU. Additional data were obtained after the analysis of anonymized hospitalization records of the 35 patients to create the BM-AspICU database. |
| Cohort No. | 38 |
| Age Group | > 18 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | The diagnosis of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) remains a challenge. Definitions of invasive fungal diseases were proposed in 2002, then updated in 2008 and in 2019, by a consensus group of the European Organization for Research and Treatment of Cancer (EORTC) and the Mycoses Study Group Education and Research Consortium (MSGERC) The EORTC/MSGERC classification is not suitable for ICU population, as immunocompetent patients admitted to the ICU for severe acute illness, while at risk for IPA, do not have the host factors described in the EORTC/ MSGERC definitions. |
| Technique | Bioinformatics analysis |
| Analysis Method | BM-AspICU algorithm |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | BM-AspICU algorithm, Aspergillus PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
