| DB ID | MyCo_1265 |
| Title | Antibody screening reveals antigenic proteins involved in Talaromyces marneffei and human interaction |
| Year | 2023 |
| PMID | 37404721 |
| Fungal Diseases involved | Talaromycosis |
| Associated Medical Condition | AIDS |
| Genus | Talaromyces |
| Species | marneffei |
| Organism | Talaromyces marneffei |
| Ethical Statement | Here obtained the human sera as anonymous blood samples from the laboratory unit (blood biobank). All patients consented to treatment at Maharaj Nakorn Chiang Mai Hospital. The consent requirement and research protocol complied with this research fall into the exemption category according to the announcement from the Research Ethics Committee of the Faculty of Medicine, Chiang Mai University. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TmMon1 |
| Biomarker Full Name | TmMon1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Thailand |
| Cohort | A cDNA library has been constructed in the previous study. Briefly, Talaromyces marneffei ATCC 200051 (CBS119456, F4) human isolated strain was cultured in a brain heart infusion broth (BHIB) at 37°C for 3 days. Total RNA was isolated from the yeast cells with TRIzol® reagent (Gibco BRL, Gaithersburg, MD, USA). |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Talaromyces marneffei is a thermally dimorphic fungus that causes the opportunistic infection, talaromycosis, mostly in immunocompromised patients such as individuals with leukemia, neutropenia, auto-interferon gamma autoantibodies, and AIDS. In fact, in T. marneffei endemic areas, infection is very common and has been recognized as a disease indicative of AIDS. There are over an estimated 8,000 cases of life-threatening T. marneffei infections annually with mortality rates of 2-75%. Lately, reports of talaromycosis in other immunologically defective patients have been increasing. T. marneffei grows as a saprophytic mold at environmental temperatures (25°C) and undergoes morphological switching to yeast-like cells at human body temperature (37°C). The route of infection is believed to be through inhalation of the conidia from the air into a patient’s lungs, especially during monsoon season. T. marneffei is primarily a pulmonary pathogen, but usually disseminates to other internal organs through lymphatic or hematogenous mechanisms in immunocompromised people. Overall, critical risk factors for T. marneffei infection are related to endemicity, seasons, and immunocompromised conditions. In most cases, the high fatality rate in patients with talaromycosis is mostly associated with delayed diagnosis. |
| Technique | Bioinformatics analysis |
| Analysis Method | Bioinformatics Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Bioinformatics Approaches |
| Up Regulation Down Regulation | Up regulated |
| Sequence Data | None |
| External Link | None |
