| DB ID | MyCo_1255 |
| Title | Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients |
| Year | 2024 |
| PMID | 38633749 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | chronic obstructive pulmonary disease (COPD) |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The studies involving humans were approved by the ethics committee of the First Affiliated Hospital of Guangzhou Medical University (Ethical number: 2018-119). The studies were conducted in accordance with the local legislation and institutional requirements. The human samples used in this study were acquired from primarily isolated as part of your previous study for which ethical approval was obtained. Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | PCT |
| Biomarker Full Name | Procalcitonin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Iran |
| Cohort | This retrospective study involved 383 hospitalized COPD patients with GOLD stages III and IV. The IPA group (67 patients) and non-IPA group (316 patients) were identi ed at the First Af liated Hospital of Guangzhou Medical University between January 2016 and February 2022. We analyzed common serological indicators in our hospital to identify predictive indicators for the early diagnosis of IPA in COPD patients. |
| Cohort No. | 383 |
| Age Group | 61-76 |
| P Value | p<0.01 |
| Sensitivity | 0.605 |
| Specificity | 0.714 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA) is an opportunistic infectious disease that poses a significant threat to immunocompromised patients, leading to severe infections and fatalities. While previous research has associated IPA primarily with conditions such as blood disorders, organ transplants, agranulocytosis, and immunosuppression, emerging evidence indicates a rising incidence of IPA in patients with chronic obstructive pulmonary disease (COPD). |
| Technique | Bioinformatics analysis |
| Analysis Method | Bioinformatics Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Bioinformatics Approach |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
