| DB ID | MyCo_1235 |
| Title | Culture-confirmed cryptococcal meningitis not detected by Cryptococcus PCR on the Biofire meningitis/encephalitis panel® |
| Year | 2018 |
| PMID | 29496598 |
| Fungal Diseases involved | Cryptococcosis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Cerebrospinal fluid (CSF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CrAg |
| Biomarker Full Name | Cryptococcal antigen |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | Singapore |
| Cohort | Here report two cases of false negative Cryptococcus results on the Biofire ME panel. The first patient was a 24-year-old-male with a history of gonadal dysgenesis and congenital pulmonary stenosis, who presented with meningitis symptoms and fever. The second patient was a 65-year-old male with a history of Hashimoto’s thyroiditis, Rheumatoid arthritis (on methotrexate), and hypertension, who presented with an altered mental state. |
| Cohort No. | 2 |
| Age Group | 24 and 65 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Analytic |
| Analysis Method | Biofire meningitis/encephalitis (ME) panel Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Biofire meningitis/encephalitis (ME) panel Analysis |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
