| DB ID | MyCo_1205 |
| Title | Elevated levels of interleukin 17A and kynurenine in candidemic patients, compared with levels in noncandidemic patients in the intensive care unit and those in healthy controls |
| Year | 2015 |
| PMID | 25149761 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | ICU Patients |
| Genus | Candida |
| Species | tropicalis |
| Organism | Candida tropicalis |
| Ethical Statement | This study was approved by the local ethical committee (19–322 ex 07/08) and was registered at Clinicaltrials.gov (clinicaltrials. gov identifier: NCT00786903). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | kynurenine |
| Biomarker Full Name | kynurenine |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | Individuals were prospectively screened for study inclusion, provided informed consent, and were assigned to one of the following 5 groups: group 1, healthy controls; group 2, patients in the ICU who were intubated, undergoing mechanical ventilation, and receiving antibiotic therapy because of extrapulmonary infection; group 3, patients in the ICU who were intubated, undergoing mechanical ventilation, and receiving antibiotic therapy because of pneumonia; and groups 4 and 5, patients with so-called late and early can- didemia, respectively. A total of 131 individuals were included in the study: 35 were in group 1, 20 were in group 2, 24 were in group 3, 27 were in group 4, and 25 were in group 5. |
| Cohort No. | 131 |
| Age Group | 17-85 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Assay |
| Analysis Method | Bio-Plex Pro Human Th17 Cytokine 5-Plex assay Bioplex200 system Kit (Biorad, Hercules, CA) |
| ELISA kits | Bio-Plex Pro Human Th17 Cytokine 5-Plex assay Bioplex200 system Kit (Biorad, Hercules, CA) |
| Assay Data | None |
| Validation Techniques used | Bio-Plex Pro Human Th17 Cytokine 5-Plex assay (Bioplex200 system) |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
