| DB ID | MyCo_1180 |
| Title | Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study |
| Year | 2017 |
| PMID | 28390391 |
| Fungal Diseases involved | Candida pneumonia |
| Associated Medical Condition | Immunocompromised and critically ill patients |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | This study was approved by the institutional review board of Taipei Veterans General Hospital (IRB approval ID: 201011002IA) and signed informed consents were obtained from all participants. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Tracheal aspirates |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | This prospective, observational study was conducted at medical and surgical ICUs in a medical center, Taipei Vet-erans General Hospital, in Taiwan, from November 2010 to October 2011. After screening 166 patients, 31 patients completed the study and were categorized into non-Candida pneumonia/non-candidemia (n = 18), suspected Candida pneumonia (n = 9), and non-Candida pneumonia/candidemia groups (n = 4). |
| Cohort No. | 166 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candida pneumonia (CP) is life-threatening and has been associated with a high attributable mortality . However, the definitive diagnosis is rarely established before over- whelming sepsis or death. Conventionally, a lung biopsy has been proposed to confirm CP, but the procedure is too risky for patients in intensive care units (ICUs) because of the high prevalence of thrombocytopenia and coagulopa-thy. Growth of respiratory Candida spp. in immuno- compromised, cancer-afflicted, and critically ill patients is frequently found, but it is usually considered colonization rather than CP. Indeed, growth of respiratory Candida spp. lacks specificity to diagnose CP, and adds little value to optimizing CP management. |
| Technique | Assay |
| Analysis Method | Glucatell kit (Associates of Cape Cod, Inc., Falmouth, MA, USA) |
| ELISA kits | Glucatell kit (Associates of Cape Cod, Inc., Falmouth, MA, USA) |
| Assay Data | None |
| Validation Techniques used | BDG-Glucatell kit assay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
