MycoBiomDB – Record Details (MyCo_1096)

Biomarker Record Details

Database ID: MyCo_1096
DB IDMyCo_1096
TitleA comprehensive diagnostic approach using galactomannan, targeted β-d-glucan, baseline computerized tomography and biopsy yields a significant burden of invasive fungal disease in at risk haematology patients
Year2014
PMID25179933
Fungal Diseases involvedInvasive fungal infection
Associated Medical ConditionHaematology patients
GenusCandida
Speciesglabrata
OrganismCandida glabrata
Ethical StatementThe study was approved by the local ethics committee and conducted in accordance with the Hel- sinki protocol (2008 revision) for medical research involving human subjects and registered with the ClinicalTrials.gov (NCT00816088).
Site of InfectionNone
Opportunistic invasiveInvasive
Sample typeBody fluid
Sample sourceSerum
Host GroupHuman
Host Common nameHuman
Host Scientific nameHomo sapiens
Biomarker NameBDG
Biomarker Full Name1-3-beta-D-Glucan
Biomarker TypeDiagnostic
BiomoleculeProtein
Geographical LocationUK
CohortA total of 203 consecutive patients were prospectively recruited from King’s College Hospital from December 2008 to May 2010.
Cohort No.203
Age Group19–73
P ValueNone
Sensitivity0.833
Specificity0.984
Positive Predictive Value0.901
MICNone
Fold ChangeNone
PathwayNone
Disease Introduction MechanismNone
TechniqueAssay
Analysis MethodBDG assay
ELISA kitsNone
Assay DataNone
Validation Techniques usedBDG Assay,GM Assay
Up Regulation Down RegulationPositive
Sequence DataNone
External LinkNone