| DB ID | MyCo_1074 |
| Title | Invasive Aspergillosis Masquerading as Multiple Pulmonary Nodules: A Challenging Diagnosis |
| Year | 2020 |
| PMID | 32566427 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | An 81-year-old man with a history of chronic lymphocytic leukemia (CLL) and acquired hypogammaglobulinemia on monthly IV immunoglobin injections, a recent history of Nocardia brain abscess for which he received a long course of trimethoprim- sulfamethoxazole/amoxicillin-clavulanate presented with a four-month history of worsening shortness of breath, was included in the study. |
| Cohort No. | 1 |
| Age Group | 81 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA) is a rare fungal infection that thrives in the setting of immunosuppression. Contributing risk factors include immunosuppression associated with hematological malignancies, hematopoietic stem cell transplant, solid organ transplant, severe neutropenia, and use of high doses of glucocorticoids. Diagnosis can be challenging with bronchoalveolar lavage cultures and serum biomarkers (galactomannan and beta-D-glucan assays) being negative, necessitating biopsy for histopathological confirmation. |
| Technique | Assay |
| Analysis Method | BDG assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | BDG Assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
