| DB ID | MyCo_1059 |
| Title | Cellular profiles of bronchoalveolar lavage fluid and their prognostic significance for non-HIV-infected patients with Pneumocystis jirovecii pneumonia |
| Year | 2015 |
| PMID | 25673796 |
| Fungal Diseases involved | Pneumocystis jirovecii pneumonia |
| Associated Medical Condition | Non-HIV-Infected Patients |
| Genus | Pneumocystis |
| Species | jirovecii |
| Organism | Pneumocystis jirovecii |
| Ethical Statement | The study was approved by the Asan Medical Center Institutional Review Board. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BAL fluid neutrophils |
| Biomarker Full Name | Bronchoalveolar lavage fluid neutrophils |
| Biomarker Type | Prognostic |
| Biomolecule | None |
| Geographical Location | Republic of Korea |
| Cohort | During the study period, a total of 209 patients with PCP were identified. Of these, 29 HIV-infected patients and 14 patients who had inadequate results for the BAL fluid cellular analysis were excluded, leaving a total of 166 patients with PCP in the final analysis. |
| Cohort No. | 166 |
| Age Group | 76 |
| P Value | p< 0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Peumocystis jirovecii pneumonia (PCP) remains one of the most prevalent and serious opportunistic infections in pa- tients with human immunodeficiency virus (HIV) infection glob- ally. Recently, PCP has been reported with increasing fre- quency in non-HIV-infected patients, particularly in those with underlying immunosuppressive conditions such as hematologic malignancies, solid tumors, collagen vascular diseases, and solid- organ transplants and those receiving immunosuppressive thera- pies. |
| Technique | Analytic |
| Analysis Method | BAL fluid cellular analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | BAL fluid cellular analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
