1MUJ Immune System date Sep 23, 2002
title Crystal Structure Of Murine Class II Mhc I-Ab In Complex With A Human Clip Peptide
authors Y.Zhu, A.Y.Rudensky, A.L.Teyton, I.A.Wilson
compound source
Molecule: H-2 Class II Histocompatibility Antigen, A-B Alpha Chain;
Chain: A
Fragment: Extracellular Alpha-1 And Extracellular Alpha-2 Domains;
Engineered: Yes
 Organism_scientific: Mus Musculus
Organism_common: Mouse
Expression_system: Drosophila Melanogaster
Expression_system_common: Fruit Fly
Expression_system_cell_line: S2
Expression_system_vector_type: Baculovirus

Molecule: H-2 Class II Histocompatibility Antigen, A Beta Chain;
Chain: B
Fragment: Extracellular Beta-1 And Extracellular Beta-2 Domains;
Engineered: Yes
Organism_scientific: Mus Musculus
Organism_common: Mouse
Expression_system: Drosophila Melanogaster
Expression_system_common: Fruit Fly
Expression_system_cell_line: S2
Expression_system_vector_type: Baculovirus

Molecule: Clip Peptide
Chain: C
Engineered: Yes
Other_details: The Peptide Was Covalently Linked To The N- Terminus Of Chain B.
Organism_scientific: Homo Sapiens
Organism_common: Human
Expression_system: Drosophila Melanogaster
Expression_system_common: Fruit Fly
Expression_system_cell_line: S2
Expression_system_vector_type: Baculovirus
symmetry Space Group: C 1 2 1
R_factor 0.220
crystal
cell
length a length b length c angle alpha angle beta angle gamma
63.647 88.065 83.740 90.00 92.48 90.00
method X-Ray Diffractionresolution 2.15 Å
ligand NAGenzyme
note 1MUJ is a representative structure
similarity Belongs to the MHC_II_beta family.
genes H2-AB1, H2-IABETA (M. musculus)
Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (83 Kb) [Save to disk]
  • LPC: Ligand-Protein Contacts for 1MUJ
  • CSU: Contacts of Structural Units for 1MUJ
  • Likely Quarternary Molecular Structure file(s) for 1MUJ
  • Structure Factors (r1mujsf.ent.Z) 308 Kb
  • Retrieve 1MUJ in mmCIF format [Save to disk]
    • View 1MUJ in 3D
  • Protein Explorer, Easier to use and more powerful than RasMol. (Win and Mac only)
  • FirstGlance in Chemscape Chime (Install Chime freeware) This is good for easiest viewing of basic structure.
  • RasMol (Install RasMol freeware) Here's help on how to use RasMol.
    • Visual 3D analysis of 1MUJ
  • STING, shows the sequence and maps the locations of sequence residues or residue ranges onto the 3D structure.
  • Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges.
  • GRASS (Graphical Representation and Analysis of Structure Server)
  • Cartoon representation from PDB Cartoon
    • Structure-derived information
  • Electro Density related parameters from EDS Electron Density Server, at Upsala
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Fold representative 1muj from FSSP and Dali (Families of Structurally Similar Proteins)
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1muj_A] [1muj_B] [1muj_C]
  • SWISS-PROT database: [HB2A_MOUSE]
  • Domain organization of [HB2A_MOUSE] by SWISSPFAM
  • Conserved protein region description, domain view and alignment from family MHC_II_beta (PF00969) of Pfam.
  • Alignments of the sequence of 1MUJ with the sequences similar proteins can be viewed for classification [HB2A_MOUSE] at ProtoMap. Click on "Neighbors List", then on the "See Alignments" button below the list.
  • A sequence distance tree ("phylogenetic tree") can be viewed for 1ACL's classification [HB2A_MOUSE] at ProtoMap. Click on the Cluster number.
    • Other resources with information on 1MUJ
  • InterPro: IPR007110 , IPR003006 , IPR003597 , IPR000353
    • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

    • You may enter another PDB ID code
    Go [Back], to the [PDB Lite page], to the [OCA Search page] or to the [PDB Home page]
    OCA© by Jaime Prilusky, 1996-2003
    Bioinformatics and Biological Computing
    Weizmann Institute of Science