OCA Atlas for 1JHT
1JHT Immune System date Jun 28, 2001
title Crystal Structure Of Hla-A20201 In Complex With A Nonameric Altered Peptide Ligand (Algigiltv) From The Mart- 1melan-A.
authors P.Sliz, O.Michielin, J.C.Cerottini, I.Luescher, P.Romero, M.Karplus, D.C.Wiley
compound source
Molecule: Hla Class I Histocompatibility Antigen, A-2 Alpha Chain;
Chain: A
Fragment: Heavy Chain
Synonym: Hla-A20201; Mhc Class I Histocompatibility Antigen Hla-A2 Alpha Chain; Mhc Class I Antigen; Lymphocyte Antigen; Mhc Class I Hla-A;
Engineered: Yes
 Organism_scientific: Homo Sapiens
Organism_common: Human
Expression_system: Escherichia Coli
Expression_system_common: Bacteria

Molecule: Beta-2-Microglobulin
Chain: B
Fragment: Beta-Chain Of Major Histocompatibility Complex Class I Molecules;
Synonym: Hla-A20201
Engineered: Yes
Organism_scientific: Homo Sapiens
Organism_common: Human
Expression_system: Escherichia Coli
Expression_system_common: Bacteria

Molecule: Nonameric Peptide Ligand From The Mart-1melan-A
Chain: C
Engineered: Yes
Mutation: Yes
Synthetic: Yes
Other_details: Standard Solid-Phase Peptide Synthesis
symmetry Space Group: P 21 21 21
R_factor 0.210
crystal
cell
length a length b length c angle alpha angle beta angle gamma
49.190 74.470 122.290 90.00 90.00 90.00
method X-Ray Diffractionresolution 2.15 Å
similarity Contains 1 immunoglobulin-like domain.[ig]
subcellular loc. Secreted.
gene B2M (H. sapiens)
function Beta-2-microglobulin is the beta-chain of major histocompatibility complex class i molecules.
disease Hemodialysis-related amyloidosis
Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (82 Kb) [Save to disk]
  • CSU: Contacts of Structural Units for 1JHT
  • Likely Quarternary Molecular Structure file(s) for 1JHT
  • Structure Factors (r1jhtsf.ent.Z) 202 Kb
  • Retrieve 1JHT in mmCIF format [Save to disk]
    • View 1JHT in 3D
  • Protein Explorer, Easier to use and more powerful than RasMol. (Win and Mac only)
  • FirstGlance in Chemscape Chime (Install Chime freeware) This is good for easiest viewing of basic structure.
  • RasMol (Install RasMol freeware) Here's help on how to use RasMol.
    • Visual 3D analysis of 1JHT
  • STING, shows the sequence and maps the locations of sequence residues or residue ranges onto the 3D structure.
  • Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges.
    • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Fold representative 1jht from FSSP and Dali (Families of Structurally Similar Proteins)
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily: CATH
  • Summaries and structural analyses of PDB data files: PDBSum
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1jht_A] [1jht_B] [1jht_C]
  • SWISS-PROT database: [B2MG_HUMAN]
  • Domain organization of [B2MG_HUMAN] by SWISSPFAM
  • Domain found in 1JHT: [IGc1 ] by SMART
  • Conserved protein region description, domain view and alignment from family ig (PF00047) of Pfam.
  • Alignments of the sequence of 1JHT with the sequences similar proteins can be viewed for classification [B2MG_HUMAN] at ProtoMap. Click on "Neighbors List", then on the "See Alignments" button below the list.
  • A sequence distance tree ("phylogenetic tree") can be viewed for 1ACL's classification [B2MG_HUMAN] at ProtoMap. Click on the Cluster number.
    • Other resources with information on 1JHT
  • InterPro: IPR003006 , IPR003597
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
    • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

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