OCA Atlas for 1HXY
1HXY Immune System Toxin date Jan 17, 2001
title Crystal Structure Of Staphylococcal Enterotoxin H In Complex With Human Mhc Class II
authors K.Petersson, M.Hakansson, H.Nilsson, G.Forsberg, L.A.Svensson, A.Liljas, B.Walse
compound source
Molecule: Hla Class II Histocompatibility Antigen, Dr Alpha Chain;
Chain: A
Engineered: Yes
 Organism_scientific: Homo Sapiens
Organism_common: Human
Expression_system: Escherichia Coli
Expression_system_common: Bacteria
Expression_system_vector_type: Plasmid
Expression_system_plasmid: Plm1

Molecule: Hla Class II Histocompatibility Antigen, Dr-1 Beta Chain;
Chain: B
Engineered: Yes
Organism_scientific: Homo Sapiens
Organism_common: Human
Expression_system: Escherichia Coli
Expression_system_common: Bacteria
Expression_system_vector_type: Plasmid
Expression_system_plasmid: Plm1

Molecule: Hemagglutinin
Chain: C
Engineered: Yes
Synthetic: Yes
Other_details: This Peptide Was Chemically Synthesized. The Sequence Of The Peptide Is Naturally Found In Influenza A Virus.;

Molecule: Enterotoxin H
Chain: D
Engineered: Yes
Organism_scientific: Staphylococcus Aureus
Organism_common: Bacteria
Expression_system: Escherichia Coli
Expression_system_common: Bacteria
Expression_system_strain: Ul635
Expression_system_vector_type: Plasmid
Expression_system_plasmid: Plr16
symmetry Space Group: C 1 2 1
R_factor 0.202
crystal
cell
length a length b length c angle alpha angle beta angle gamma
123.624 122.843 48.513 90.00 100.13 90.00
method X-Ray Diffractionresolution 2.60 Å
ligand ZNenzyme
similarity Belongs to the MHC_II_beta family.
Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (115 Kb) [Save to disk]
  • LPC: Ligand-Protein Contacts for 1HXY
  • CSU: Contacts of Structural Units for 1HXY
  • Likely Quarternary Molecular Structure file(s) for 1HXY
  • Structure Factors (r1hxysf.ent.Z) 187 Kb
  • Retrieve 1HXY in mmCIF format [Save to disk]
    • View 1HXY in 3D
  • Protein Explorer, Easier to use and more powerful than RasMol. (Win and Mac only)
  • FirstGlance in Chemscape Chime (Install Chime freeware) This is good for easiest viewing of basic structure.
  • RasMol (Install RasMol freeware) Here's help on how to use RasMol.
    • Visual 3D analysis of 1HXY
  • STING, shows the sequence and maps the locations of sequence residues or residue ranges onto the 3D structure.
  • Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges.
    • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Fold representative 1hxy from FSSP and Dali (Families of Structurally Similar Proteins)
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1hxy_A] [1hxy_B] [1hxy_C] [1hxy_D]
  • SWISS-PROT database: [HB2F_HUMAN]
  • Domain organization of [HB2F_HUMAN] by SWISSPFAM
  • Domain found in 1HXY: [IGc1 ] by SMART
  • Conserved protein region description, domain view and alignment from family MHC_II_beta (PF00969) of Pfam.
  • Alignments of the sequence of 1HXY with the sequences similar proteins can be viewed for classification [HB2F_HUMAN] at ProtoMap. Click on "Neighbors List", then on the "See Alignments" button below the list.
  • A sequence distance tree ("phylogenetic tree") can be viewed for 1ACL's classification [HB2F_HUMAN] at ProtoMap. Click on the Cluster number.
    • Other resources with information on 1HXY
  • InterPro: IPR003006 , IPR003597 , IPR000353
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
    • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

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